Luis Diaz, M.D.

Phone: (410) 955-8964

Titles

Assistant Professor of Oncology

Schools/Degrees

M.D., University of Michigan

Training

Intern, Department of Medicine, Johns Hopkins University School of Medicine
Fellow in Medical Oncology, Johns Hopkins Kimmel Cancer Center

Certifications

Internal Medicine and Medical Oncology

Clinical Interests

GI Cancers (Colorectal Cancer, Pancreatic Cancers)
Urologic Cancers (Prostate, Renal and Bladder Cancers)

Watch Dr. Diaz discuss coordinated care of colon cancer patients

Research Summary

My goal is to combine world-class basic science research with clinical knowledge to produce novel diagnostic, predictive and therapeutic agents for cancer patients.  My area of concentration in the laboratory has been in the preclinical development of the concept of COBALT (Combination Bacteriolytic Therapy) as well as in the development of a clinical protocol for testing this concept. I have focused on the preclinical development of COBALT and am involved in the development of future therapeutic agents from the Vogelstein/Kinzler Laboratories.

Journal Citations

Diehl, F., Schmidt, K., Choti, M.A., Romans, K., Goodman, S., Li, M., Thornton, K., Agrawal, N., Sokoll, L., Szabo, S.A., Kinzler, K.W., Vogelstein, B., and Diaz, L.A., Jr. (2008). Circulating mutant DNA to assess tumor dynamics. Nature medicine 14, 985-990.

Herman, J.M., Swartz, M.J., Hsu, C.C., Winter, J., Pawlik, T.M., Sugar, E., Robinson, R., Laheru, D.A., Jaffee, E., Hruban, R.H., Campbell, K.A., Wolfgang, C.L., Asrari, F., Donehower, R., Hidalgo, M., Diaz, L.A., Jr., Yeo, C., Cameron, J.L., Schulick, R.D., and Abrams, R. (2008). Analysis of fluorouracil-based adjuvant chemotherapy and radiation after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas: results of a large, prospectively collected database at the Johns Hopkins Hospital. J Clin Oncol 26, 3503-3510.

Parsons, D.W., Jones, S., Zhang, X., Lin, J.C., Leary, R.J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.M., Gallia, G.L., Olivi, A., McLendon, R., Rasheed, B.A., Keir, S., Nikolskaya, T., Nikolsky, Y., Busam, D.A., Tekleab, H., Diaz, L.A., Jr., Hartigan, J., Smith, D.R., Strausberg, R.L., Marie, S.K., Shinjo, S.M., Yan, H., Riggins, G.J., Bigner, D.D., Karchin, R., Papadopoulos, N., Parmigiani, G., Vogelstein, B., Velculescu, V.E., and Kinzler, K.W. (2008). An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812.

Sur, S., Pagliarini, R., Bunz, F., Rago, C., Diaz, L.A. Jr., Kinzler, K.W., Vogelstein, B., and Papadopoulos, N. (2009). A new panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53. PNAS. 106, 3964-3969.

Cheong, I., X. Huang, K. Thornton, L. A. Diaz, Jr., and S. Zhou. 2007. Targeting cancer with bugs and liposomes: ready, aim, fire. Cancer Res 67:9605-8.

Diaz, L. A., C. A. Foss, K. Thornton, S. Nimmagadda, C. J. Endres, O. Uzuner, T. M. Seyler, S. D. Ulrich, J. Conway, C. Bettegowda, N. Agrawal, I. Cheong, X. Zhang, P. W. Ladenson, B. N. Vogelstein, M. A. Mont, S. Zhou, K. W. Kinzler, B. Vogelstein, and M. G. Pomper. 2007. Imaging of Musculoskeletal Bacterial Infections by [I]FIAU-PET/CT. PLoS ONE 2:e1007.

Rago, C., D. L. Huso, F. Diehl, B. Karim, G. Liu, N. Papadopoulos, Y. Samuels, V. E. Velculescu, B. Vogelstein, K. W. Kinzler, and L. A. Diaz, Jr. 2007. Serial assessment of human tumor burdens in mice by the analysis of circulating DNA. Cancer Res 67:9364-70

Bettegowda, C., Foss, C. A., Cheong, I., Wang, Y., Diaz, L., Agrawal, N., Fox, J., Dick, J., Dang, L. H., Zhou, S., Kinzler, K. W., Vogelstein, B. & Pomper, M. G. (2005). Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil. Proc Natl Acad Sci U S A 102, 1145-50.

Bettegowda, C., Huang, X., Lin, J., Cheong, I., Kohli, M., Szabo, S. A., Zhang, X., Diaz, L. A., Jr., Velculescu, V. E., Parmigiani, G., Kinzler, K. W., Vogelstein, B. & Zhou, S. (2006). The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT. Nat Biotechnol.

Cummins, J. M., He, Y., Leary, R. J., Pagliarini, R., Diaz, L. A., Jr., Sjoblom, T., Barad, O., Bentwich, Z., Szafranska, A. E., Labourier, E., Raymond, C. K., Roberts, B. S., Juhl, H., Kinzler, K. W., Vogelstein, B. & Velculescu, V. E. (2006). The colorectal microRNAome. Proc Natl Acad Sci U S A 103, 3687-92.

Diehl, F., Li, M., Dressman, D., He, Y., Shen, D., Szabo, S., Diaz, L. A., Jr., Goodman, S. N., David, K. A., Juhl, H., Kinzler, K. W. & Vogelstein, B. (2005). Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc Natl Acad Sci U S A 102, 16368-73.

Peters, B. A., Diaz, L. A., Polyak, K., Meszler, L., Romans, K., Guinan, E. C., Antin, J. H., Myerson, D., Hamilton, S. R., Vogelstein, B., Kinzler, K. W. & Lengauer, C. (2005). Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nat Med 11, 261-2.

Samuels, Y., Diaz, L. A., Jr., Schmidt-Kittler, O., Cummins, J. M., Delong, L., Cheong, I., Rago, C., Huso, D. L., Lengauer, C., Kinzler, K. W., Vogelstein, B. & Velculescu, V. E. (2005). Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 7, 561-73.

Xu, J., Sauvageot, J., Ewing, C. M., Sun, J., Liu, W., Isaacs, S. D., Wiley, K. E., Diaz, L., Zheng, S. L., Walsh, P. C. & Isaacs, W. B. (2006). Germline ATBF1 mutations and prostate cancer risk. Prostate 66, 1082-5.

Ellerin, TB, and LA Diaz, Jr. Evidence-based Medicine: 500 Clues to Diagnosis and Treatment. (Philadelphia: Lippincott Williams & Wilkins, June 2001).

Wang TL, Diaz LA Jr, Romans K, Bardelli A, Saha S, Galizia G, Choti M, Donehower R, Parmigiani G, Shih IeM, Iacobuzio-Donahue C, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE. Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3089-94.

Agrawal N, Chetan Bettegowda, Ian Cheong, Jean-Francois Geschwind, Charles G. Drake, Edward L. Hipkiss, Mitsuaki Tatsumi, Long H. Dang, Luis A. Diaz, Jr., Martin Pomper, Mohammad Abusedera, Richard L. Wahl, Kenneth W. Kinzler, Shibin Zhou, David L. Huso, and Bert Vogelstein. Bacteriolytic therapy can generate a potent immune response against experimental tumors.  Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15172-7.

Bettegowda C, Catherine A. Foss, Ian Cheong,  Nishant Agrawal, Long H. Dang, Luis A. Diaz, Jr, Yuchuan Wang,  James Fox, Shibin Zhou, Kenneth Kinzler, Bert Vogelstein, Martin G. Pomper. Imaging bacterial infections with radiolabeled FIAU. Proc Natl Acad Sci U S A. Jan 25;102(4):1145-50, 2005.

Peters BA., Luis A. Diaz, Jr., Kornelia Polyak, Kathy Romans, Eva C. Guinan, Joseph H. Antin, Michael Collector,  Sol Sarkis, Kenneth W. Kinzler, Bert Vogelstein, Christoph Lengauer.  Contribution of bone-marrowed derived stem cells to human tumor vasculature. Nature Medicine. in press 2005. Diaz, LA, Jr. The Clinical Value of Genomic Instability.  Semin in Cancer Biology. 15(1) 67-71, 2005.

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