David Sidransky, M.D.
Fax: (410)614-1411
Interests:
- Molecular Cancer Detection and Staging
Titles
Professor of Otolaryngology - Head and Neck Surgery
Professor of Oncology
Professor of Pathology
Professor of Cellular & Molecular Medicine
Professor of Urology
Director, Head and Neck Cancer Research
Principal Investigator, Johns Hopkins Head and Neck Cancer SPORE
Schools/Degrees
M.D., Baylor College of Medicine
Training
Intern in Internal Medicine Clinical Investigator Program Univer Dr. Thomas Caskey
Chief Resident in Internal Medicine, Baylor College of Medicine, Houston, TX
Senior Clinical Fellow in Oncology Research Fellow in Oncology, Univer Dr. Bert Vogelstein, The Johns Hopkins University School of Medicine, Baltimore, MD
Certifications
Internal Medicine
Oncology
Head and Neck Surgery
Clinical Interests
Head and Neck Cancer
Lung Cancer
Research Summary
In this laboratory, we elucidate the molecular genetic changes that drive the progression of various types of cancer. We concentrate on identifying new genetic changes in smoking-associated tumors including lung cancer, head and neck cancer, and bladder cancer. We also investigate the molecular epidemiology of smoking-induced cancers and the link between tobacco smoke and mutations of critical oncogenes. Two recent discoveries are now driving our basic research—p63, a p53 family member, is commonly amplified in SCC and drives cancer progression. We know that WT p53 binds to p63 and degrades p63. Moreover, p63 binds to B56/PP2A, resulting in upregulation of b-catenin and downstream signaling. We also recently discovered BRAF mutations in 70 percent of thyroid tumors. We are identifying downstream signaling mechanisms for BRAF and are working with new BRAF inhibitors for targeted molecular therapy.
Our laboratory is best known for our efforts in molecular-detection approaches based on the identification of clonal genetic changes in many bodily fluids, including urine, saliva, stool and blood. Several major recent innovations in this area have been pioneered by our laboratory. Many of these approaches, such as the hypermethylation of p16 in human cancers and the discovery of mitochondrial mutations at high frequency in many tumor types have shed new light in the field of cancer biology and detection. We also discovered that circulating free DNA was in fact derived from tumor cells by showing that this DNA shared the identical genetic changes present in the primary tumor. This approach may one day lead to a simple blood test to detect cancers at an early stage. Our team also has led new approaches in molecular staging based on the identification of micrometastatic disease in various tumors. This approach may one day be the standard for staging patients with cancer and will allow for more aggressive therapy in patients with minimal residual disease. No matter what area we research, we always try to bridge basic research into the clinical setting.
Journal Citations
Poeta,M.L., Manola,J., Goldwasser,M.A., Forastiere,A., Benoit,N., Califano, J.A., Ridge,J.A., Goodwin,J., Kenady, D., Saunders,J., Westra,W., Sidransky,D., Koch, W.M. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med 357(25): 2552-2561, 2007
Huang,Y., Hoque,M.O., Wu,F., Trink,B., Sidransky,D., Ratovitski,E.A. Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes. Cell Cycle 7(11):1613-1622, 2008
Dasgupta,S., Hoque,M.O., Upadhyay,S., Sidransky,D. Mitochondrial cytochrome B gene mutation promotes tumor growth in bladder cancer. Cancer Res 68(3):700-706,2008
Hoque, M.O., Kim,M.S., OStrow,K.L., Liu,J., Wisman,G.B., Park, H.L., Poeta, M.L., Jeronimo, C., Henrique,R., Lendvai,A., Schuuring, E., Begum, S., Rosenbaum,E., Ongenaert,M., Yamashita, K., Califano, J., Westra, W., van der Zee, A.G., Van Criekinge, W., Sidransky, D. Genome-wide promoter analysis uncovers portions of the cancer methylome. Cancer Res 68(8):2661-2670, 2008
Chatterjee,A., Upadhyay,S., Chang,X., Nagpal, J.K., Trink,B., Sidransky,D. U-box-type ubiquitin E$ ligase, UFD2a attenuates cisplatin medicated degradation of DeltaNp63alpha. Cell Cycle 7(9):1231-1237, 2008
Huang, Y., Sen, T., Nagpal, J., Upadhyay, S., Trink, B., Ratovitski, E., Sidransky, D. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell Cycle 7(18):2846-55, 2008
Brait, M., Begum, S., Carvalho, AL., Dasgupta, S., Vettore, AL., Czerniak, B., Caballero, OL., Westra, WH., Sidransky, D., Hoque, MO. Aberrant promoter methylation of multiple genes during pathogenesis of bladder cancer. Cancer Epidemiol Biomarkers Prev. 17(10):2786-94, 2008
Chang, SS., Jiang, WW., Smith, I., Poeta, LM., Begum, S., Glazer, C., Shan, S., Westra, W., Sidransky, D., Califano, JA. MicroRNA alterations in head and neck squamous cell carcinoma. Int J Cancer 123(12):2791-7, 2008
Ostrow, KL., Park, HL., Hoque, MO., Kim, MS., Liu, J., Argani, P., Westra, W., VanCriekinge, W., Sidransky, D. Pharmacologic unmasking of epigenetically silenced genes in breast cancer. Clin Cancer Res. 15(4):1184-91, 2009
Dasgupta, Yung, Westra, Rini, Brandes, Sidransky. Following mitochondrial footprints through a long mucosal path to lung cancer. PLoS One. 4(8):e6533, 2009
Kim, Louwagie, Carvalho, Terhaar Sive Droste, Park, Chae, Yamashita, Liu, Ostrow, Ling, Guerrero-Preston, Demokan, Yalniz, Dalay, Meijer, Van Criekinge, Sidransky. Promoter DNA methylation of oncostatin m receptor-beta as a novel diagnostic and therapeutic marker in colon cancer. PLoS One. 4(8):e6555, 2009
Brait, M., Begum, S., Carvalho, A.L., Dasgupta, S., Vettore, A.L., Czerniak, B., Caballero, O.L., Westra, W.H., Sidransky, D., and Hoque, M.O. (2008). Aberrant promoter methylation of multiple genes during pathogenesis of bladder cancer. Cancer Epidemiol Biomarkers Prev 17, 2786-2794.
Chae, Y.K., Kang, S.K., Kim, M.S., Woo, J., Lee, J., Chang, S., Kim, D.W., Kim, M., Park, S., Kim, I., Keam, B., Rhee, J., Koo, N.H., Park, G., Kim, S.H., Jang, S.E., Kweon, I.Y., Sidransky, D., and Moon, C. (2008). Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML). PLoS ONE 3, e2594.
Chae, Y.K., Woo, J., Kim, M.J., Kang, S.K., Kim, M.S., Lee, J., Lee, S.K., Gong, G., Kim, Y.H., Soria, J.C., Jang, S.J., Sidransky, D., and Moon, C. (2008). Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer. PLoS ONE 3, e2162.
Chang, S.S., Jiang, W.W., Smith, I., Poeta, L.M., Begum, S., Glazer, C., Shan, S., Westra, W., Sidransky, D., and Califano, J.A. (2008). MicroRNA alterations in head and neck squamous cell carcinoma. Int J Cancer 123, 2791-2797.
Chatterjee, A., Chang, X., Nagpal, J.K., Chang, S., Upadhyay, S., Califano, J., Trink, B., and Sidransky, D. (2008). Targeting human 8-oxoguanine DNA glycosylase to mitochondria protects cells from 2-methoxyestradiol-induced-mitochondria-dependent apoptosis. Oncogene 27, 3710-3720.
Chatterjee, A., Upadhyay, S., Chang, X., Nagpal, J.K., Trink, B., and Sidransky, D. (2008). U-box-type ubiquitin E4 ligase, UFD2a attenuates cisplatin mediated degradation of DeltaNp63alpha. Cell cycle (Georgetown, Tex 7, 1231-1237.
Cui, Y., Ying, Y., van Hasselt, A., Ng, K.M., Yu, J., Zhang, Q., Jin, J., Liu, D., Rhim, J.S., Rha, S.Y., Loyo, M., Chan, A.T., Srivastava, G., Tsao, G.S., Sellar, G.C., Sung, J.J., Sidransky, D., and Tao, Q. (2008). OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation. PLoS ONE 3, e2990.
Dasgupta, S., Hoque, M.O., Upadhyay, S., and Sidransky, D. (2008). Mitochondrial cytochrome B gene mutation promotes tumor growth in bladder cancer. Cancer Res 68, 700-706.
Gorelik, B., Ziv, I., Shohat, R., Wick, M., Hankins, W.D., Sidransky, D., and Agur, Z. (2008). Efficacy of weekly docetaxel and bevacizumab in mesenchymal chondrosarcoma: a new theranostic method combining xenografted biopsies with a mathematical model. Cancer Res 68, 9033-9040.
Ha, P.K., Chang, S.S., Glazer, C.A., Califano, J.A., and Sidransky, D. (2008). Molecular techniques and genetic alterations in head and neck cancer. Oral Oncol. 45, 335-339.
Hoque, M.O., Begum, S., Brait, M., Jeronimo, C., Zahurak, M., Ostrow, K.L., Rosenbaum, E., Trock, B., Westra, W.H., Schoenberg, M., Goodman, S.N., and Sidransky, D. (2008). Tissue inhibitor of metalloproteinases-3 promoter methylation is an independent prognostic factor for bladder cancer. The Journal of urology 179, 743-747.
Hoque, M.O., Kim, M.S., Ostrow, K.L., Liu, J., Wisman, G.B., Park, H.L., Poeta, M.L., Jeronimo, C., Henrique, R., Lendvai, A., Schuuring, E., Begum, S., Rosenbaum, E., Ongenaert, M., Yamashita, K., Califano, J., Westra, W., van der Zee, A.G., Van Criekinge, W., and Sidransky, D. (2008). Genome-wide promoter analysis uncovers portions of the cancer methylome. Cancer Res 68, 2661-2670.
Huang, Y., Hoque, M.O., Wu, F., Trink, B., Sidransky, D., and Ratovitski, E.A. (2008). Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes. Cell cycle (Georgetown, Tex 7, 1613-1622.
Huang, Y., Sen, T., Nagpal, J., Upadhyay, S., Trink, B., Ratovitski, E., and Sidransky, D. (2008). ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. Cell cycle (Georgetown, Tex 7, 2846-2855.
Jakupciak, J.P., Maragh, S., Markowitz, M.E., Greenberg, A.K., Hoque, M.O., Maitra, A., Barker, P.E., Wagner, P.D., Rom, W.N., Srivastava, S., Sidransky, D., and O'Connell, C.D. (2008). Performance of mitochondrial DNA mutations detecting early stage cancer. BMC Cancer 8, 285.
Jeronimo, C., Monteiro, P., Henrique, R., Dinis-Ribeiro, M., Costa, I., Costa, V.L., Filipe, L., Carvalho, A.L., Hoque, M.O., Pais, I., Leal, C., Teixeira, M.R., and Sidransky, D. (2008). Quantitative hypermethylation of a small panel of genes augments the diagnostic accuracy in fine-needle aspirate washings of breast lesions. Breast Cancer Res Treat 109, 27-34.
Kang, S.K., Chae, Y.K., Woo, J., Kim, M.S., Park, J.C., Lee, J., Soria, J.C., Jang, S.J., Sidransky, D., and Moon, C. (2008). Role of human aquaporin 5 in colorectal carcinogenesis. The American journal of pathology 173, 518-525.
Kim, M.S., Lebron, C., Nagpal, J.K., Chae, Y.K., Chang, X., Huang, Y., Chuang, T., Yamashita, K., Trink, B., Ratovitski, E.A., Califano, J.A., and Sidransky, D. (2008). Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer. Biochem Biophys Res Commun 370, 38-43.
Liu, J.W., Nagpal, J.K., Jeronimo, C., Lee, J.E., Henrique, R., Kim, M.S., Ostrow, K.L., Yamashita, K., van Criekinge, V., Wu, G., Moon, C.S., Trink, B., and Sidransky, D. (2008). Hypermethylation of MCAM gene is associated with advanced tumor stage in prostate cancer. Prostate 68, 418-426.
Liu, J.W., Nagpal, J.K., Sun, W., Lee, J., Kim, M.S., Ostrow, K.L., Zhou, S., Jeronimo, C., Henrique, R., Van Criekinge, W., Moon, C.S., Califano, J.A., Trink, B., and Sidransky, D. (2008). ssDNA-binding protein 2 is frequently hypermethylated and suppresses cell growth in human prostate cancer. Clin Cancer Res 14, 3754-3760.
Maragh, S., Jakupciak, J.P., Wagner, P.D., Rom, W.N., Sidransky, D., Srivastava, S., and O'Connell, C.D. (2008). Multiple strand displacement amplification of mitochondrial DNA from clinical samples. BMC medical genetics 9, 7.
Moon, C.S., Agbo, E.C., and Sidransky, D. (2008). Slow development impedes the uptake of diagnostics. Nature 451, 16.
Nagpal, J.K., Dasgupta, S., Jadallah, S., Chae, Y.K., Ratovitski, E.A., Toubaji, A., Netto, G.J., Eagle, T., Nissan, A., Sidransky, D., and Trink, B. (2008). Profiling the expression pattern of GPI transamidase complex subunits in human cancer. Mod Pathol 21, 979-991.
Park, H.L., Kim, M.S., Yamashita, K., Westra, W., Carvalho, A.L., Lee, J., Jiang, W.W., Baek, J.H., Liu, J., Osada, M., Moon, C.S., Califano, J.A., Mori, M., and Sidransky, D. (2008). DCC promoter hypermethylation in esophageal squamous cell carcinoma. Int J Cancer 122, 2498-2502.
Park, J.C., Chae, Y.K., Son, C.H., Kim, M.S., Lee, J., Ostrow, K., Sidransky, D., Hoque, M.O., and Moon, C. (2008). Epigenetic silencing of human T (brachyury homologue) gene in non-small-cell lung cancer. Biochem Biophys Res Commun 365, 221-226.
Sidransky, D. (2008). The oral cavity as a molecular mirror of lung carcinogenesis. Cancer prevention research (Philadelphia, Pa) 1, 12-14.
Tokumaru, Y., Yamashita, K., Kim, M.S., Park, H.L., Osada, M., Mori, M., and Sidransky, D. (2008). The role of PGP9.5 as a tumor suppressor gene in human cancer. Int J Cancer 123, 753-759.
Westra, W.H., Taube, J.M., Poeta, M.L., Begum, S., Sidransky, D., and Koch, W.M. (2008). Inverse Relationship between Human Papillomavirus-16 Infection and Disruptive p53 Gene Mutations in Squamous Cell Carcinoma of the Head and Neck. Clin Cancer Res 14, 366-369.
Woo, J., Chae, Y.K., Jang, S.J., Kim, M.S., Baek, J.H., Park, J.C., Trink, B., Ratovitski, E., Lee, T., Park, B., Park, M., Kang, J.H., Soria, J.C., Lee, J., Califano, J., Sidransky, D., and Moon, C. (2008). Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium. Biochem Biophys Res Commun 366, 321-327.
Woo, J., Lee, J., Chae, Y.K., Kim, M.S., Baek, J.H., Park, J.C., Park, M.J., Smith, I.M., Trink, B., Ratovitski, E., Lee, T., Park, B., Jang, S.J., Soria, J.C., Califano, J.A., Sidransky, D., and Moon, C. (2008). Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation. Cancer Lett 264, 54-62.
Woo, J., Lee, J., Kim, M.S., Jang, S.J., Sidransky, D., and Moon, C. (2008). The effect of aquaporin 5 overexpression on the Ras signaling pathway. Biochem Biophys Res Commun 367, 291-298.
Ball, D. W., N. Jin, D. M. Rosen, A. Dackiw, D. Sidransky, M. Xing, and B. D. Nelkin. 2007. Selective growth inhibition in BRAF mutant thyroid cancer by the mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244. J Clin Endocrinol Metab 92:4712-8.
Carvalho, A. L., C. Jeronimo, M. M. Kim, R. Henrique, Z. Zhang, M. O. Hoque, S. Chang, M. Brait, C. S. Nayak, W. W. Jiang, Q. Claybourne, Y. Tokumaru, J. Lee, D. Goldenberg, E. Garrett-Mayer, S. Goodman, C. S. Moon, W. Koch, W. H. Westra, D. Sidransky, and J. A. Califano. 2008. Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma. Clin Cancer Res 14:97-107.
Couch, M. E., R. L. Ferris, J. A. Brennan, W. M. Koch, E. M. Jaffee, M. S. Leibowitz, G. T. Nepom, H. A. Erlich, and D. Sidransky. 2007. Alteration of cellular and humoral immunity by mutant p53 protein and processed mutant peptide in head and neck cancer. Clin Cancer Res 13:7199-206.
Jiang, W. W., M. Zahurak, Z. T. Zhou, H. L. Park, Z. M. Guo, G. J. Wu, D. Sidransky, B. Trink, and J. A. Califano. 2007. Alterations of GPI transamidase subunits in head and neck squamous carcinoma. Mol Cancer 6:74.
Kim, M. S., K. Yamashita, Y. K. Chae, Y. Tokumaru, X. Chang, M. Zahurak, M. Osada, H. L. Park, A. Chuang, J. A. Califano, and D. Sidransky. 2007. A promoter methylation pattern in the N-methyl-D-aspartate receptor 2B gene predicts poor prognosis in esophageal squamous cell carcinoma. Clin Cancer Res 13:6658-65.
Liu, C., S. Zhou, S. Begum, D. Sidransky, W. H. Westra, M. Brock, and J. A. Califano. 2007. Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer. Lung Cancer 55:303-11.
Moon, C. S., E. C. Agbo, and D. Sidransky. 2008. Slow development impedes the uptake of diagnostics. Nature 451:16.
Osada, M., H. L. Park, M. J. Park, J. W. Liu, G. Wu, B. Trink, and D. Sidransky. 2007. A p53-type response element in the GDF15 promoter confers high specificity for p53 activation. Biochem Biophys Res Commun 354:913-8.
Park, J. C., Y. K. Chae, C. H. Son, M. S. Kim, J. Lee, K. Ostrow, D. Sidransky, M. O. Hoque, and C. Moon. 2008. Epigenetic silencing of human T (brachyury homologue) gene in non-small-cell lung cancer. Biochem Biophys Res Commun 365:221-6.
Poeta, M. L., J. Manola, M. A. Goldwasser, A. Forastiere, N. Benoit, J. A. Califano, J. A. Ridge, J. Goodwin, D. Kenady, J. Saunders, W. Westra, D. Sidransky, and W. M. Koch. 2007. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med 357:2552-61.
Seng, T. J., J. S. Low, H. Li, Y. Cui, H. K. Goh, M. L. Wong, G. Srivastava, D. Sidransky, J. Califano, R. D. Steenbergen, S. Y. Rha, J. Tan, W. S. Hsieh, R. F. Ambinder, X. Lin, A. T. Chan, and Q. Tao. 2007. The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation. Oncogene 26:934-44.
Sidransky, D., Chatterjee,A., Chang,X., Nagpal, J., Chang,S., Upadhyay, Califano,J., Trink, B. 2007. Targeting Human 8-Oxoguanine DNA Glycosylase (hOGG1) to mitochondria protects cells from 2-methoxyestradiol-induced mitochondria dependent apoptosis. Oncogene Impress.
Sidransky, D., Nagpal,J., Dasgupta,S., Jadallah,S., Chae, Y., Ratovitski,E., Taubaji,A., Netto,G., Eagle,T., Trink,B. . 2008. Profiling the expression pattern of GPI transamidase complex subunits in human cancer. Oncogene Impress.
Trink, B., M. Osada, E. Ratovitski, and D. Sidransky. 2007. p63 transcriptional regulation of epithelial integrity and cancer. Cell Cycle 6:240-5.
Upadhyay, S., A. Chatterjee, B. Trink, M. Sommer, E. Ratovitski, and D. Sidransky. 2007. TAp63gamma regulates hOGG1 and repair of oxidative damage in cancer cell lines. Biochem Biophys Res Commun 356:823-8.
Westra, W. H., J. M. Taube, M. L. Poeta, S. Begum, D. Sidransky, and W. M. Koch. 2008. Inverse relationship between HPV16 infection and disruptive p53 gene mutations in squamous cell carcinoma of the head and neck. Clin Cancer Res.
Woo, J., J. Lee, M. S. Kim, S. J. Jang, D. Sidransky, and C. Moon. 2007. The effect of aquaporin 5 overexpression on the Ras signaling pathway. Biochem Biophys Res Commun.
Woo, J., Y. K. Chae, S. J. Jang, M. S. Kim, J. H. Baek, J. C. Park, B. Trink, E. Ratovitski, T. Lee, B. Park, M. Park, J. H. Kang, J. C. Soria, J. Lee, J. Califano, D. Sidransky, and C. Moon. 2008. Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium. Biochem Biophys Res Commun 366:321-7.
Zhou, S., S. Kachhap, W. Sun, G. Wu, A. Chuang, L. Poeta, L. Grumbine, S. K. Mithani, A. Chatterjee, W. Koch, W. H. Westra, A. Maitra, C. Glazer, M. Carducci, D. Sidransky, T. McFate, A. Verma, and J. A. Califano. 2007. Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proc Natl Acad Sci U S A 104:7540-5.
Benoit, N. E., Goldenberg, D., Deng, S. X., Rosenbaum, E., Cohen, Y., Califano, J. A., Shackelford, W. H., Wang, X. B. & Sidransky, D. (2005). Colorimetric approach to high-throughput mutation analysis. Biotechniques 38, 635-9.
Chatterjee, A., Mambo, E. & Sidransky, D. (2006). Mitochondrial DNA mutations in human cancer. Oncogene 25, 4663-74.
Chatterjee, A., Mambo, E., Osada, M., Upadhyay, S. & Sidransky, D. (2006). The effect of p53-RNAi and p53 knockout on human 8-oxoguanine DNA glycosylase (hOgg1) activity. FASEB J 20, 112-4.
Chatterjee, A., Mambo, E., Zhang, Y., Deweese, T. & Sidransky, D. (2006). Targeting of mutant hogg1 in mammalian mitochondria and nucleus: effect on cellular survival upon oxidative stress. BMC Cancer 6, 235.
Costanzi, J., Sidransky, D., Navon, A. & Goldsweig, H. (2005). Ribonucleases as a novel pro-apoptotic anticancer strategy: review of the preclinical and clinical data for ranpirnase. Cancer Invest 23, 643-50.
Davison, J. M., Rosenbaum, E., Barrett, T. L., Goldenberg, D., Hoque, M. O., Sidransky, D. & Westra, W. H. (2005). Absence of V599E BRAF mutations in desmoplastic melanomas. Cancer 103, 788-92.
Galen, N., Pilch, B. Z., Westra, W. H., Sidransky, D. (2006). Squamous dysplasia of the hypopharynx, larynx and trachea. In: W.H.O. classification of tumours: pathology and genetics of tumours of the head and neck (Barnes L, E. J., Reichart PA, Sidransky D, ed.). IARC Press, Lyon.
Goldenberg-Cohen, N., Cohen, Y., Rosenbaum, E., Herscovici, Z., Chowers, I., Weinberger, D., Pe'er, J. & Sidransky, D. (2005). T1799A BRAF mutations in conjunctival melanocytic lesions. Invest Ophthalmol Vis Sci 46, 3027-30.
Henrique, R., Costa, V. L., Cerveira, N., Carvalho, A. L., Hoque, M. O., Ribeiro, F. R., Oliveira, J., Teixeira, M. R., Sidransky, D. & Jeronimo, C. (2006). Hypermethylation of Cyclin D2 is associated with loss of mRNA expression and tumor development in prostate cancer. J Mol Med 84, 911-8.
Henrique, R., Jeronimo, C., Hoque, M. O., Carvalho, A. L., Oliveira, J., Teixeira, M. R., Lopes, C. & Sidransky, D. (2005). Frequent 14-3-3 sigma promoter methylation in benign and malignant prostate lesions. DNA Cell Biol 24, 264-9.
Henrique, R., Jeronimo, C., Hoque, M. O., Nomoto, S., Carvalho, A. L., Costa, V. L., Oliveira, J., Teixeira, M. R., Lopes, C. & Sidransky, D. (2005). MT1G hypermethylation is associated with higher tumor stage in prostate cancer. Cancer Epidemiol Biomarkers Prev 14, 1274-8.
Henrique, R., Jeronimo, C., Teixeira, M. R., Hoque, M. O., Carvalho, A. L., Pais, I., Ribeiro, F. R., Oliveira, J., Lopes, C. & Sidransky, D. (2006). Epigenetic heterogeneity of high-grade prostatic intraepithelial neoplasia: clues for clonal progression in prostate carcinogenesis. Mol Cancer Res 4, 1-8.
Hoque, M. O., Begum, S., Topaloglu, O., Chatterjee, A., Rosenbaum, E., Van Criekinge, W., Westra, W. H., Schoenberg, M., Zahurak, M., Goodman, S. N. & Sidransky, D. (2006). Quantitation of promoter methylation of multiple genes in urine DNA and bladder cancer detection. J Natl Cancer Inst 98, 996-1004.
Hoque, M. O., Feng, Q., Toure, P., Dem, A., Critchlow, C. W., Hawes, S. E., Wood, T., Jeronimo, C., Rosenbaum, E., Stern, J., Yu, M., Trink, B., Kiviat, N. B. & Sidransky, D. (2006). Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer. J Clin Oncol 24, 4262-9.
Hoque, M. O., Rosenbaum, E., Westra, W. H., Xing, M., Ladenson, P., Zeiger, M. A., Sidransky, D. & Umbricht, C. B. (2005). Quantitative assessment of promoter methylation profiles in thyroid neoplasms. J Clin Endocrinol Metab 90, 4011-8.
Hoque, M. O., Soria, J. C., Woo, J., Lee, T., Lee, J., Jang, S. J., Upadhyay, S., Trink, B., Monitto, C., Desmaze, C., Mao, L., Sidransky, D. & Moon, C. (2006). Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth. Am J Pathol 168, 1345-53.
Hoque, M. O., Topaloglu, O., Begum, S., Henrique, R., Rosenbaum, E., Van Criekinge, W., Westra, W. H. & Sidransky, D. (2005). Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects. J Clin Oncol 23, 6569-75.
Hu, S., Ewertz, M., Tufano, R. P., Brait, M., Carvalho, A. L., Liu, D., Tufaro, A. P., Basaria, S., Cooper, D. S., Sidransky, D., Ladenson, P. W. & Xing, M. (2006). Detection of serum deoxyribonucleic acid methylation markers: a novel diagnostic tool for thyroid cancer. J Clin Endocrinol Metab 91, 98-104.
Jakupciak, J. P., Wang, W., Markowitz, M. E., Ally, D., Coble, M., Srivastava, S., Maitra, A., Barker, P. E., Sidransky, D. & O'Connell, C. D. (2005). Mitochondrial DNA as a cancer biomarker. J Mol Diagn 7, 258-67.
Jiang, W. W., Masayesva, B., Zahurak, M., Carvalho, A. L., Rosenbaum, E., Mambo, E., Zhou, S., Minhas, K., Benoit, N., Westra, W. H., Alberg, A., Sidransky, D., Koch, W. & Califano, J. (2005). Increased mitochondrial DNA content in saliva associated with head and neck cancer. Clin Cancer Res 11, 2486-91.
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