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Hopkins Kimmel Cancer Center

Research Programs

CANCER BIOLOGY

In Cancer Biology, our researchers work to reveal and understand the various steps that cause a normal cell to turn malignant.  From molecular genetic alterations—those that change cells by mutating its DNA—to epigenetic alterations—those that change cells without a mutation, investigators are uncovering and understanding key genes and gene pathways involved in cancer.  Starting with a cell’s earliest origins as a stem cell through its evolution to malignant cell, researchers are deciphering the biological transformations that lead to cancer and those that occur in the tumor cell to cause it grow and spread.  This ever growing understanding of the cellular origins and promoters of cancer has resulted in new tests for early cancer detection and cancer susceptibility, new diagnostic methods using molecular markers of cancer, opportunities to prevent cancer, and new treatments.  Program leaders are Drs. Steve Baylin and Victor Velculescu.

Faculty

NCI CCC

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Johns Hopkins Kimmel Cancer Center Johns Hopkins Department of Otolaryngology Johns Hopkins Kimmel Cancer Center